Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease
نویسندگان
چکیده
منابع مشابه
Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases
The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets. We aimed to use data from the Resource for Genetic Epidemiology Research on Adult Health and Aging (GERA) study to search for SNP-SNP interactions associated w...
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With the recent explosion in high-throughput genotyping technology, the amount and quality of single-nucleotide polymorphism (SNP) data has increased exponentially. Therefore, the identification of SNP interactions that are associated with common diseases is playing an increasing and important role in interpreting the genetic basis of disease susceptibility and in devising new diagnostic tests ...
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متن کاملMultiple testing for SNP-SNP interactions.
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction patterns given as expressions linked by logical operators. Methods for multiple testing in high-dimensional settings can be applied when many SNPs are considered simultaneously. However, another less we...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2012
ISSN: 1088-9051
DOI: 10.1101/gr.137885.112